The opening tie between North African rivals Morocco and Egypt tips off at 13:00 GMT with defending champions Nigeria taking on Cameroon at 15:00 GMT.
Co-Hosts of the competition, Senegal and Tunisia, round up the quarterfinal games with ties against Angola and Democratic Republic of Congo respectively.
All four ties have interesting story lines with the North African showdown set to feature one of the surprise packages at this tournament, Morocco against 2015 quarter finalist Egypt; Morocco beat record winners Angola 60-53 at the preliminary stage to qualify as Group B leaders.
2015 bronze medalist Tunisia take on Congo who qualified behind Nigeria after stunning the defending champs 83-77 in Group A.
However, the biggest matchup of the round is between Senegal and record winners Angola with both teams featuring in the last four of the 2015 edition; Angola placed second while Senegal placed fourth in the competition.
Semifinal games take place on Friday September 15 with the final round of games set to take place a day later.
By Yaw Adjei-Mintah
@YawMintYM on Twitter
